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Along with Peter C. Doherty , he shared the Nobel Prize in Physiology or Medicine for the discovery of how the immune system recognizes virus-infected cells. Together with the Australian Peter C. Doherty he received the Nobel Prize in Physiology or Medicine for the discovery of how the immune system recognizes virus-infected cells.

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With this he became the 24th Swiss Nobel laureate. In he was awarded an honorary Companion of the Order of Australia AC , Australia's highest civilian honour, for his scientific work with Doherty. Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses cannot reproduce. Zinkernagel and Doherty discovered that for killer T-cells to recognize infected cells, they had to recognize two molecules on the surface of the cell—not only the virus antigen, but also a molecule of the major histocompatibility complex MHC.

This recognition was done by a T-cell receptor on the surface of the T-cell.

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The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Doherty discovered that the MHC was responsible for the body fighting meningitis viruses too. In he became a member of the German Academy of Sciences Leopoldina. Contents move to sidebar hide. Article Talk.